EXPRESSION OF DNAJB12 OR DNAJB14 CAUSES COORDINATE INVASION OF THE NUCLEUS BY MEMBRANES ASSOCIATED WITH A NOVEL NUCLEAR PORE STRUCTURE.

Expression of DNAJB12 or DNAJB14 causes coordinate invasion of the nucleus by membranes associated with a novel nuclear pore structure.

DNAJB12 and DNAJB14 are transmembrane proteins in the endoplasmic reticulum (ER) that serve as co-chaperones for Hsc70/Hsp70 heat shock proteins.We demonstrate that over-expression of DNAJB12 or DNAJB14 causes the formation of elaborate membranous structures within cell nuclei, which we SLEEP TIGHT MELATONIN designate DJANGOS for DNAJ-associated nu

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